How to prepare a dental collagen membrane?

Dental collagen membranes are mainly derived from tendons, dermis, skin, or pericardium, usually from bovine or porcine sources. So how should a dental collagen membrane be prepared? What are its classifications? What characteristics should a dental collagen membrane have? The following are some of them.

Here is the content list:

• Preparation methods

• Classification

• Characteristics that should be present

Preparation methods

Typically, most barrier membranes are cross-linked to prolong uptake and reduce antigenicity. In addition, the extent to which the collagen barrier is cross-linked may also affect the outcome of treatment. Cross-linking can be introduced by physical or chemical reagents. The cross-linking of collagenous tissue significantly reduces the antigenicity and biodegradability of the implant, and the membrane barrier become suturable and the resorption time longer for required new bone formation.

The main sterilization method is to irradiate collagen with gamma radiation. Irradiation has two main effects on collagen: initiation of random cross-linking and destruction of some part of the original collagen molecule.

Classification

Dental collagen membranes used for GBR technology can be divided into two categories: non-resorbable and absorbable. Non-resorbable membranes are biologically inert and require a second surgical procedure to remove them after bone regeneration is complete. Resorbable membranes are naturally biodegradable and have different absorption rates. However, all dental collagen membranes, whether non-resorbable or resorbable, differ in their biomaterial and physical properties, with associated advantages and disadvantages for different clinical situations.

Characteristics that should be present

To determine which membrane material to use, consider the following characteristics that the ideal dental collagen membrane should have.

Histocompatibility

Ideally, dental collagen membranes should be biocompatible, facilitating the absence of inflammation or interaction between the dental collagen membrane and the host tissue to avoid wound dehiscence or infection.

Space Maintenance

Dental collagen membranes should have the ability to maintain space to allow the bone regeneration process to take place. Adequate dental collagen membrane stiffness is paramount to maintain space and prevent defect collapse.

Stabilization of blood clots

Dental collagen membranes should have the ability to stabilize blood clots to allow the regenerative process to proceed and reduce the integration of connective tissue into the defect.

Cellular Occlusivity

The surface of the dental collagen membrane should prevent the invasion of fibrous tissue into the graft site, which is directly related to the porosity of the dental collagen membrane. Larger pores may inhibit bone formation by allowing overgrowth of faster-growing cells. When the pore size is too small, cell migration is restricted and collagen deposition is not possible, resulting in the formation of avascular tissue.

Guangdong Victory Biotech Co., Ltd. produces dental collagen membranes with all of these characteristics. If you would like to know more about dental collagen membranes, please contact us.