The production of three bone graft substitutes

Bone grafts are used in a variety of surgical procedures designed to promote new bone growth to repair bone defects, enhance bone growth at specific sites, promote fusion of adjacent bone. Thereby restoring and improvnig the stability of the skeletal structure and reducing the back and leg pain suffered by the affected individual. In many cases, the surgical procedure combines the use of bone graft with any one of several tools, such as pedicle screws and rods.

Here is the content:

• Promoting New Bone Growth

• Induction of new bone formation

• Treatment of bone defects and induction of new bone formation

Promoting New Bone Growth

There is an alternative: autologous bone graft substitute compositions (abgs), which can be used as an alternative to autologous grafts to promote new bone growth, which compositions comprise:

• Autologous blood (ab).

• Osteogenic bone morphogenetic protein (bmp).

• A coagulant, selected from ionic solutions or pharmacologically acceptable calcium salts in nanoparticles and ca++ microsphere couples; and a compression-resistant matrix (crm).

Wherein said autologous blood forms a coagulant gel of collagen bone graft substitutes comprising an osteogenic bone morphogenetic protein, a calcium salt, and a compression-resistant matrix (hereinafter referred to as crm). The bone-forming bone morphogenetic proteins are selected from: bmp-6, bmp-2, bmp-7, bmp-4, bmp-5, bmp-6, bmp-9, bmp-12, and bmp-13, their analogs, their heterodimers, and combinations thereof. Very suitable osteogenic bone morphogenetic proteins are bmp-6 or bmp-7, preferably bmp-6.

Induction of new bone formation

Another autologous bone graft substitute composition for implants that induce new bone formation and promote bone growth comprises:

• Autologous blood.

• An osteogenic bone morphogenetic protein (selected from: bmp-6, bmp-2, bmp-7, bmp-4, bmp-5, bmp-8, bmp-9, bmp-12, and bmp-13, their analogs, their heterodimers, and combinations thereof).

• A compression-resistant matrix (crm).

Wherein said autologous blood forms a coagulum gel of collagen bone graft substitutes comprising osteogenic bone morphogenetic protein and crm. A suitable osteogenic bone morphogenic protein is bmp-6. In addition to the osteogenic bone morphogenic protein bmp-6, osteogenic bone morphogenic proteins selected from bmp-6, bmp-2, bmp-7, bmp-4, bmp-5, bmp-8, bmp-9, bmp-12, and bmp-13, their analogs, heterodimers thereof, and combinations thereof may be used.

Treatment of bone defects and induction of new bone formation

A further collagen bone graft substitute block composition for the treatment of bone defects, induction of new bone formation, and promotion of bone growth comprises:

• Autologous blood,

• Osteogenic bone morphogenetic proteins (selected from: bmp-6, bmp-2, bmp-7, bmp-4, bmp-5, bmp-8, bmp-9, bmp-12, and bmp-13, their analogues, their heterodimers, and (combinations of them).

• Coagulants (selected from ionic solutions or pharmacologically acceptable calcium salts in nanoparticles and ca++ microsphere couples)

Wherein said autologous blood forms a coagulant gel of collagen bone graft substitutes comprising osteogenic bone morphogenetic protein and calcium salts. Suitable bone-forming bone morphogenetic proteins are bmp-6 or bmp-7, preferably bmp-6 said autologous blood (ab) further comprises plasma enriched with autologous or allogeneic platelets (prp) or autologous blood (ab) is replaced by plasma enriched with autologous platelets (prp).

The method of preparation of the composition and the kit for preparing the implanted composition, said composition being capable of mimicking a "living autograft" for the treatment of bone defects, induction of new bone formation and promotion of bone growth. In particular, the present invention relates to injectable/extrudable/implantable autologous bone graft substitute compositions (hereinafter referred to as abgs) for the treatment of bone defects. The induction of new bone formation and the promotion of bone growth for fracture healing and spinal fusion to repair bone defects in orthopedic and oral maxillofacial dental surgery in bone reconstruction operations.

Guangdong Victory Biotech Co. Ltd. , with 2,000 ㎡ of floor space, a subsidiary of SHENGUAN HOLDINGS (GROUP) LIMITED, is located in Foshan, Guangdong Province, China, and has more than 15 years of experience in the field of collagen research and development. We have been specializing in the manufacturing of medical grade collagen, supplying atelocollagen of low pyrogen to the market. If you are interested, please contact us without hesitation.